Nature of "allopurinol oxidizing enzyme" from mouse liver

Activation of allopurinol oxidizing enzyme activity of the dialysate of mouse liver supernatant by monovalent cations.

The quinine-oxidizing enzyme and liver aldehyde oxidase.

A derivative of quinine formed in minced rabbit liver has been isolated by Kelsey et al. (I), and identified by Mead and Koepfli (2) as a carbostyril. Hence quinine is oxidized in liver with replacement of the hydrogen atom in position 2 of the quinoline ring by a hydroxy group. Analogous oxidation products are excreted by men receiving the four principal cinchona alkaloids. This change is impo...

Some Properties of Thiosulfate-Oxidizing Enzyme from Marine Heterotroph 16B.

Thiosulfate-oxidizing enzyme has been demonstrated in cell-free extracts of the marine, thiosulfate-oxidizing pseudomonad strain 16B. The enzyme, partially purified by ion-exchange chromatography and calcium phosphate gel treatment, catalyzed the oxidation of thiosulfate to tetrathionate with the concomitant reduction of ferricyanide. Native but not mammalian cytochrome c was also reduced by th...

Indoleacetic Acid Oxidizing Enzyme & Inhibitors from Light-Grown Cotton.

Cytochrome P450 Enzyme Inhibitors from Nature

Cytochrome P450 (CYP) is a heme containing enzyme superfamily that catalyzes the oxidative biotransformation of lipophilic substrates to hydrophilic metabolites facilitating their removal from cells. The CYPs were first recognized by Martin Klingenberg (Klingenberg, 1958) while studying the spectrophotometric properties of pigments in a microsomal fraction prepared from rat livers. When a dilut...